I reckon the next big thing relates to taking computers and gadgets to being literally a part of us...!!!
We basically have our mobiles with us 24/7... On the horizon is Google Glass and other similar devices, iwatches and so forth.. We'll be wearing microprocessors, you'll find them in your shoes, on your jacket, on your hat, gloves etc.. I've seen many such prototypes with many different functions in the media from medical, safety, geo spatial etc.. So the development of such apps will be a big area for sure...
In fact the technology is out there that we can even implant chips into the body and can think of commands which are transmitted like turning a light switch on/off etc... and of course all plugged into the super information highway...
So I would say take your pick ;-) Tons to choose from....