But there's no single "magic" configuration that works for everyone; it always depends on your hardware and, of course, the type of website (whether it's a WordPress site, an online store, etc.). However, in cPanel, PHP-FPM usually works well, and enabling OPache is essential. There are other configurations as well, and you can certainly use LiteSpeed to serve static files quickly. It's just that it's complicated; ultimately, what delivers real speed is almost always a fast disk + caching + PHP-FPM.