Personally, I'll amend my former post with this:
Redis and PHP_FPM.
I've not tested others, but having Redis and PHP_FPM setup managed to get my test development to under 1 second from certain places.
YMMV, for me it works a treat. Others will have their own opinion.
LSCache, Redis, Opcache, Memcached, PHP_FPM. Redis is usually around the same popularity as LSCache. Others say Varnish.
Then you get into the whole web server thing, NGINX, Apache, Litespeed.
What kind of website are you talking about caching? Is it a static website? Wordpress? Drupal? Any sort of CMS?