IF you are asking if you should email people that are not on your list then I say no. You could do it but many will report you as Spam and this could become a problem for you if too many people report you.
A question I have is why would you want to send emails to those that unsubscribed? They obviously aren't interested in what you have to offer so the emails would probably be a waste of your time as well.
People unsubscribe for a reason, therefore you shouldn't email them anymore, besides if people start marking you as spam it could end your whole business.
a BIG NO, when people subscribes to your list, they are giving you the "go signal" to receive some emails. but when they unsubscribe they revoke that right.
If you happen to still send to those who unsubscribe, then that's called SPAMMING which put your autoresponder and business at risk.